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Urology 189 , 1926 (2024)

conducted a CRISPR/Cas9 genetic screen with KEAP1 -mutant lung cancer cells and found that NRF2-addicted cancer cells are highly dependent on glutamine uptake, and that, consequently, inhibition of glutamine-derived glutamate by glutaminase inhibition effectively suppresses NRF2-addicted lung cancers (Romero et al